//The IRF4 gene regulatory module functions as a read-write integrator to dynamically coordinate T helper cell fate

The IRF4 gene regulatory module functions as a read-write integrator to dynamically coordinate T helper cell fate

Roger Sciammas, one of the newest CCM faculty members, recently published his first UCD research paper in the Journal, Immunity, “The IRF4 gene regulatory module functions as a read-write integrator to dynamically coordinate T helper cell fate”.   The authors (Veena Krishnamoorthy, Sunil Kannanganat, Mark Maienschein-Cline, Sarah L. Cook, Jianjun Chen, Neil Bahroos, Evelyn Sievert, Emily Corse, Anita Chong and Roger Sciammas) show that the Irf4 locus “senses” the intensity of T cell receptor signaling to scale expression of IRF4. Differential binding of IRF4 to divergent DNA sequences is controlled by the amounts of IRF4 expressed and coordinates alternate T helper cell fate choice. Thus, IRF4 expression links TCR signal strength to T helper cell fate determination.  More information on Dr. Sciammas work can be found by clicking here.

2018-05-31T15:50:40+00:00