Grant Content https://ccm.ucdavis.edu/article-type/grant Grant Content for CENTER FOR COMPARATIVE MEDICINE en Article: "Prediction of Spillover and Interventional Animal Vaccination to Prevent Emerging Pathogen Threats in Current and Future Zones of US Military Operation" https://ccm.ucdavis.edu/news/awarded-project-preventing-emerging-pathogenic-threats-preempt <p><span><span><span><span><img alt="Preempt Program Picture" data-entity-type="file" data-entity-uuid="a13ca3c0-0888-4294-9b51-8205b5a5a275" height="192" src="/sites/g/files/dgvnsk6356/files/inline-images/preemptpic_0.jpg" width="341" class="align-left" />DARPA (Defense Advanced Research Projects Agency) issued a Broad Agency Announcement in January 2018 entitled "<em>PREventing EMerging Pathogenic Threats - PREEMPT</em>" to "a new layer of medical preparedness to combat emerging infectious diseases".  The basis for DARPA interest in this topic is that almost 60% of emerging infectious diseas February 19, 2019 - 8:05am Anonymous https://ccm.ucdavis.edu/news/awarded-project-preventing-emerging-pathogenic-threats-preempt Awarded Project: "Salmonella-specific Th1 cell function and residence" https://ccm.ucdavis.edu/grant/awarded-project-salmonella-specific-th1-cell-function-and-residence <h2>Salmonella-specific Th1 cell function and residence</h2> <p>Dr. Stephen J. McSorley was awarded a five year grant from the National Institute of Allergy and Infectious Diseases, NIH.  Systemic Salmonella infections are responsible for almost 1 million deaths annually and there is an urgent need to understand the mechanisms of protective immunity. Host CD4 T cells responses are critical for protective immunity to Salmonella in humans and in mouse models but there is a knowledge gap in relation to the functional requirements for memory CD4 T cells during a protective response. January 10, 2019 - 4:27pm Christine Herkenrath https://ccm.ucdavis.edu/grant/awarded-project-salmonella-specific-th1-cell-function-and-residence Awarded Project: "NIAID Centers of Excellence for Influenza Research and Surveillance" https://ccm.ucdavis.edu/grant/awarded-project-niaid-centers-excellence-influenza-research-and-surveillance <h2>NIAID Centers of Excellence for Influenza Research and Surveillance</h2> <p>Dr. Christopher J. Miller, in conjunction with the St. Jude Children's Research Hospital, received a two year contract from the National Institute of Allergy and Infectious Diseases, NIH.  <span><span><span><span>Seasonal influenza A virus (IAV) infections kill up to 49,000 people in the United States each year.</span></span> <span><span>Pandemics can kill many more people, and considerable scientific effort is directed to addressing pandemics prophylactically because responses after a pandemic are too late. January 01, 2019 - 1:35pm Christine Herkenrath https://ccm.ucdavis.edu/grant/awarded-project-niaid-centers-excellence-influenza-research-and-surveillance Awarded Project: "Role of female genital mucosa associated CD4 T cells in vaccine-induced HIV susceptibility" https://ccm.ucdavis.edu/news/awarded-project-role-female-genital-mucosa-associated-cd4-t-cells-vaccine-induced-hiv <h2>Role of female genital mucosa associated CD4 T cells in vaccine-induced HIV susceptibility</h2> <p>Dr. Smita Iyer received a two year award.  The majority of HIV infections by heterosexual transmission occur in women; understanding factors contributing to this increased risk is critical to prevent HIV infection in women and curb the global HIV/AIDS pandemic. This proposal uses robust complementary approaches and cutting-edge immunological tools to address this concern. Accomplishment of proposed goals will aid in designing interventions in women to prevent HIV infection.</p> December 05, 2018 - 2:01pm Christine Herkenrath https://ccm.ucdavis.edu/news/awarded-project-role-female-genital-mucosa-associated-cd4-t-cells-vaccine-induced-hiv Awarded Project: "Defining Protective and Disease-Reducing Immunity to Borrelia Burgdorferi Infection" https://ccm.ucdavis.edu/grant/awarded-project-defining-protective-and-disease-reducing-immunity-borrelia-burgdorferi <h2>Defining Protective and Disease-Reducing Immunity to Borrelia Burgdorferi Infection  </h2> <p>Dr. Nicole Baumgarth was awarded a three year project through the DoD Congressionally Directed Medical Research Program to work on a Lyme disease study.   <span><span>Following infection with Borrelia burgdorferi, the causative agent of Lyme disease, antibodies are generated that can reduce the number of Borrelia in the infected host, but they cannot totally eliminate the infection. September 30, 2018 - 1:35pm Christine Herkenrath https://ccm.ucdavis.edu/grant/awarded-project-defining-protective-and-disease-reducing-immunity-borrelia-burgdorferi Awarded Project: "Immune Mechanisms Underlying Age-Related Neurodegeneration in HIV Infection" https://ccm.ucdavis.edu/news/awarded-project-immune-mechanisms-underlying-age-related-neurodegeneration-hiv-infection <h2>Immune Mechanisms Underlying Age-Related Neurodegeneration in HIV Infection</h2> <p>Dr. Smita Iyer received a fiver year grant from the National Institute on Aging, NIH to study age-related neurodegeneration related to HIV infection.  <span><span><span><span><span><span>An estimated 50% of HIV-infected patients on antiretroviral therapy develop neurocognitive disorders. This proposal uses robust powerful and complementary approaches to understand the immune mechanisms underlying age- related neurodegeneration during HIV infection. September 30, 2018 - 12:54pm Christine Herkenrath https://ccm.ucdavis.edu/news/awarded-project-immune-mechanisms-underlying-age-related-neurodegeneration-hiv-infection Awarded Project: "Bay Area CRISPR Reporters" https://ccm.ucdavis.edu/grant/awarded-project-bay-area-crispr-reporters <h2>Bay Area CRISPR Reporters </h2> <p>Dr. K.C. Kent Lloyd received a UC Multiple-Campus Award from the Office of the Director, NIH to participate with UCSF on Bay Area CRISPR Reporters.  <span><span><span><span>A growing momentum and an ever-increasing body of evidence indicates that gene editing will become a standard treatment in therapeutic settings.  And although proof-of-principle and validation projects have demonstrated activity in cells and to some degree, in animal models, more work needs to be done in characterizing the activity of various gene  editing modalities. September 15, 2018 - 9:42am Christine Herkenrath https://ccm.ucdavis.edu/grant/awarded-project-bay-area-crispr-reporters Awarded Project: "Estrogen reverses progestin-mediated increases in susceptibility to genital virus pathogens" https://ccm.ucdavis.edu/grant/awarded-project-estrogen-reverses-progestin-mediated-increases-susceptibility-genital-virus <h2>Estrogen reverses progestin-mediated increases in susceptibility to genital virus pathogens </h2> <p>Dr. Christopher J. September 01, 2018 - 4:01pm Christine Herkenrath https://ccm.ucdavis.edu/grant/awarded-project-estrogen-reverses-progestin-mediated-increases-susceptibility-genital-virus Article: "Prevention of HIV-1 transmission by CD4-mimetic small-molecule entry inhibitors" https://ccm.ucdavis.edu/grant/article-prevention-hiv-1-transmission-cd4-mimetic-small-molecule-entry-inhibitors <h2>Prevention of HIV-1 transmission by CD4-mimetic small-molecule entry inhibitors</h2> <p>Dr. Christopher J. Miller, in conjunction with the Dana-Farber Cancer Institute, Inc., received a four year grant from the National Institutes of Allergy and Infectious Diseases, NIH.  <span><span>The global AIDS pandemic is sustained by continued sexual transmission of the etiologic agent, human immunodeficiency virus (HIV-1). July 01, 2018 - 1:28pm Christine Herkenrath https://ccm.ucdavis.edu/grant/article-prevention-hiv-1-transmission-cd4-mimetic-small-molecule-entry-inhibitors Awarded Project: "Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin Secretion" https://ccm.ucdavis.edu/news/dr-roger-sciammas-receives-2-year-grant-national-institute-allergy-and-infectious-diseases <h2>Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin Secretion</h2> <div> <div> <div> <div> <div> <div> <p>Dr. Roger Sciammas recently received a two year grant from the National Institute of Allergy and Infectious Diseases (NIAID), NIH to study the “Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin Secretion”.  Secreted antibodies are primary immunological proteins important for protection to microbial agents yet pathological if produced in excess. Because of this balance, the control of secretion is tightly regulated. May 31, 2018 - 2:10pm Christine Herkenrath https://ccm.ucdavis.edu/news/dr-roger-sciammas-receives-2-year-grant-national-institute-allergy-and-infectious-diseases