DMPA

Awarded Project: "Estrogen reverses progestin-mediated increases in susceptibility to genital virus pathogens"

September 01, 2018
Estrogen reverses progestin-mediated increases in susceptibility to genital virus pathogens 

Dr. Christopher J. Miller, in conjunction with Stanford University, received a five year grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development, NIH.  Prior work from our research group revealed that while depot-medroxyprogesterone acetate (DMPA) and other progestins used for contraception compromise genital mucosal barrier function, treatment of humanized mice with DMPA and estrogen (E) restores barrier integrity and blocks genital HIV transmission.