Professional Research Immunologist
Center for Comparative Medicine
California National Primate Research Center
University of CA, Davis
Research Interests: My experience spans over 30 years of research focused primarily on microsporidiosis using mice, monkeys, and humans to study natural history of infection, drug discovery and efficacy, diagnostics, molecular epidemiology, molecular genetics, and immunology related to T-cell-dependent and macrophage-mediated responses. Opportunistic microsporidia infections associated with AIDS dramatically declined and my area of research transitioned to studies on innate immunity related to inflammation and aging in collaboration with Dr. Marcelo Kuroda. These studies focus on the contributions of myeloid cells (monocytes, macrophages, neutrophils) to natural aging in the rhesus macaque model as well as in the accelerated aging that occurs in SIV-infected rhesus macaques as a model for HIV infections of humans. Our long-term goals are to target macrophages to reduce chronic inflammation associated with diseases of aging as well as remove a virus reservoir to help achieve HIV cure.