H. pylori Pathogenesis
Helicobacter pylori is a bacterial pathogen that infects the stomach of half the world’s population. Although most infected people will have no clinical signs or symptoms, about 10% will develop peptic ulcer disease or gastric cancer, which is the second most common cause of cancer death in the world. The Solnick laboratory has developed the non-human primate model of H. pylori that most closely mimics human infection. The rhesus model, together with elegant mouse models that exploit state-of-the-art targeted genomics, are used to better understand the complex interaction of this persistent bacterial pathogen with its human host.