Article: "The IRF4 gene regulatory module functions as a read-write integrator to dynamically coordinate T helper cell fate"

Roger Sciammas, PhDRoger Sciammas, one of the newest CCM faculty members, recently published his first UCD research paper in the Journal, Immunity, “The IRF4 gene regulatory module functions as a read-write integrator to dynamically coordinate T helper cell fate”.   The authors (Veena Krishnamoorthy, Sunil Kannanganat, Mark Maienschein-Cline, Sarah L. Cook, Jianjun Chen, Neil Bahroos, Evelyn Sievert, Emily Corse, Anita Chong and Roger Sciammas) show that the Irf4 locus “senses” the intensity of T cell receptor signaling to scale expression of IRF4. Differential binding of IRF4 to divergent DNA sequences is controlled by the amounts of IRF4 expressed and coordinates alternate T helper cell fate choice. Thus, IRF4 expression links TCR signal strength to T helper cell fate determination. 

IRF4 Gene Illustration

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