Dr. Stephen McSorley receives 5-year grant from the National Institute of Allergy and Infectious Diseases (NIAID)
Stephen McSorley recently received a five year grant from the National Institute of Allergy and Infectious Diseases (NIAID) to study “Target antigen identification to improve Salmonella vaccination” (R01AI139410). Systemic Salmonella infections cause 1 million deaths every year and there is an urgent need for a sub-unit vaccine that could be administered to infants and other vulnerable individuals. A major difference between a protective live Salmonella vaccine and a less effective sub-unit vaccine is the ability of the live vaccine to elicit tissue-resident memory (TRM) responses. This application will focus on the protective role of Salmonella-specific TRM T cells, identify the unique antigens recognized by this protective population and then examine whether the antigens can be used to improve the efficacy of a sub-unit Salmonella vaccine.