Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin Secretion
Dr. Roger Sciammas recently received a two year grant from the National Institute of Allergy and Infectious Diseases (NIAID), NIH to study the “Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin Secretion”. Secreted antibodies are primary immunological proteins important for protection to microbial agents yet pathological if produced in excess. Because of this balance, the control of secretion is tightly regulated. Secretion is initiated in a cell stage-specific manner by an exchange of mRNA isoforms coding for antibody; however, although this mRNA swap was characterized over 30 years ago, the switch for this swap has remained elusive. This project aims to uncover the nature of this molecular switch. We anticipate that the results of our research will ultimately illuminate how we could reconfigure the switch to reset the balance in antibody-based protection or disease.