Targeting Macrophages in Aging SIV-Infected Rhesus Macaques
Dr. Marcelo Kuroda and Dr. Elizabeth Didier were awarded a four year grant from the National Heart, Lung, and Blood Institute at NIH. The proposed research is relevant to public health for testing an intervention strategy to alleviate chronic
inflammation and disease associated with accelerated aging during HIV infection and antiretroviral therapy.
This study utilizes a nonhuman primate model of SIV infection, antiretroviral therapies, and aging to determine
if targeting macrophages with bisphosphonates will provide proof of principle for efficacy. The results are
anticipated to move work forward to reverse or delay progression of inflammatory diseases associated with
HIV infection, antiretroviral therapies, and accelerated aging in humans.