How did a vaccine enhance HIV acquisition
Dr. Christopher J. Miller was awarded a five year grant from the National Institute of Allergy and Infectious Diseases, NIH. In the STEP trial of an Ad5 vectored HIV vaccine, more people receiving the vaccine than the placebo became HIV-infected. The proposed studies will determine how this occurred. We will use a monkey model of AIDS for these studies where increased virus acquisition in animals getting the same vaccine has been shown. Understanding how a vaccine increased HIV infections will allow us to avoid testing a harmful HIV vaccine in people.