Awarded Project: "Role of IRF4 in T Helper Cell Fate Decisions"

Role of IRF4 in T Helper Cell Fate Decisions 

Dr. Roger Sciammas received a five year grant from the National Institute of Allergy and Infectious Diseases, NIH.  Vaccines are powerful tools of preventative medicine which have re-defined the quality of public health; however, in addition to targeting key antigens, how vaccines could be modified to guide the immune response is still not clear. This project focuses on genetic pathways within T helper cells that function to appropriately tailor the immune response to bacterial, viral, or fungal pathogens.  We hope to identify basic systems that guide these cells towards optimal protection, so we can then  improve vaccine methodology for the future.