Functional Plasticity in the Helicobacter pylori Type IV Secretion System
Dr. Jay V. Solnick was awarded a five year grant through the National Institutes for Allergy and Infectious Diseases, NIH. Helicobacter pylori is a bacterial pathogen that commonly infects the human stomach and causes inflammation that sometimes leads to peptic ulcers or gastric cancer, but more often is asymptomatic, and may even protect against some other diseases. We recently discovered a novel strategy that the bacterium uses to turn on or turn off its capacity to cause inflammation. The studies proposed here seek to understand the bacterial and host factors that underlie this observation.