Awarded Project: "CD4 T cell responses to Chlamydia infection"

CD4 T cell responses to Chlamydia infection

Dr. Stephen J. McSorley received a four year grant from the National Institute of Allergy and Infectious Diseases, NIH.  The CDC estimates that Chlamydia is one of the most prevalent bacterial infections in the US and causes upper reproductive tract pathology in a growing number of otherwise health young  women. Unfortunately, women with untreated Chlamydia infection can develop serious pelvic  inflammatory disease (PID), infertility, chronic pelvic pain, or suffer from ectopic pregnancy. Given the  igh incidence of infection and the potential for serious pathology, the current consensus among  scientists and clinicians is that an effective Chlamydia vaccine is needed. In order for a vaccine to be generated, greater understanding of host immunity to Chlamydia infection in the upper reproductive tract is required. Our application will utilize new antigen-specific reagents that we have recently  generated for the mouse model of genital Chlamydia infection. We will use these reagents to examine the heterogeneity of the CD4 T cell response to infection, the affect of antibiotic treatment on developing immunity, and boosting protective immunity to infection.