Bay Area CRISPR Reporters
Dr. K.C. Kent Lloyd received a UC Multiple-Campus Award from the Office of the Director, NIH to participate with UCSF on Bay Area CRISPR Reporters. A growing momentum and an ever-increasing body of evidence indicates that gene editing will become a standard treatment in therapeutic settings. And although proof-of-principle and validation projects have demonstrated activity in cells and to some degree, in animal models, more work needs to be done in characterizing the activity of various gene editing modalities. The Bay Area CRISPR Reporters project proposal builds on extensive team-driven expertise, resources, and leadership skills of the two established University of California PIs located at UCD (Lloyd) and UCSF (McManus) to generate reporter mice that, when edited, brightly and robustly provide a fluorescent, luminescent, and visual stain to enable facile and quantitative evaluation of gene editing in mice.