Prevention of HIV-1 transmission by CD4-mimetic small-molecule entry inhibitors
Dr. Christopher J. Miller, in conjunction with the Dana-Farber Cancer Institute, Inc., received a four year grant from the National Institutes of Allergy and Infectious Diseases, NIH. The global AIDS pandemic is sustained by continued sexual transmission of the etiologic agent, human immunodeficiency virus (HIV-1). We will investigate whether a pod-intravaginal ring can deliver a recently developed small-molecule virus entry inhibitor to the vaginal tract and thereby establish a long-term block to HIV-1 sexual infection. We will also test whether the small molecule can increase the protective efficacy of antibodies elicited by an HIV-1 vaccine.