Grant

Article: "Prediction of Spillover and Interventional Animal Vaccination to Prevent Emerging Pathogen Threats in Current and Future Zones of US Military Operation"

February 19, 2019

DARPA (Defense Advanced Research Projects Agency) issued a Broad Agency Announcement in January 2018 entitled "PREventing EMerging Pathogenic Threats - PREEMPT" to "a new layer of medical preparedness to combat emerging infectious diseases".  The basis for DARPA interest in this topic is that almost 60% of emerging infectious diseases in humans are transmitted from an animal species harboring the pathogen that is then subsequently transmitted to humans, known as a zoonotic transmission.  Emerging infections also result from insect species, such as mosquitos, that transmit novel vir

Awarded Project: "Salmonella-specific Th1 cell function and residence"

January 10, 2019
Salmonella-specific Th1 cell function and residence

Dr. Stephen J. McSorley was awarded a five year grant from the National Institute of Allergy and Infectious Diseases, NIH.  Systemic Salmonella infections are responsible for almost 1 million deaths annually and there is an urgent need to understand the mechanisms of protective immunity. Host CD4 T cells responses are critical for protective immunity to Salmonella in humans and in mouse models but there is a knowledge gap in relation to the functional requirements for memory CD4 T cells during a protective response.

Awarded Project: "NIAID Centers of Excellence for Influenza Research and Surveillance"

January 01, 2019
NIAID Centers of Excellence for Influenza Research and Surveillance

Dr. Christopher J. Miller, in conjunction with the St. Jude Children's Research Hospital, received a two year contract from the National Institute of Allergy and Infectious Diseases, NIH.  Seasonal influenza A virus (IAV) infections kill up to 49,000 people in the United States each year. Pandemics can kill many more people, and considerable scientific effort is directed to addressing pandemics prophylactically because responses after a pandemic are too late.

Awarded Project: "Role of female genital mucosa associated CD4 T cells in vaccine-induced HIV susceptibility"

December 05, 2018
Role of female genital mucosa associated CD4 T cells in vaccine-induced HIV susceptibility

Dr. Smita Iyer received a two year award.  The majority of HIV infections by heterosexual transmission occur in women; understanding factors contributing to this increased risk is critical to prevent HIV infection in women and curb the global HIV/AIDS pandemic. This proposal uses robust complementary approaches and cutting-edge immunological tools to address this concern. Accomplishment of proposed goals will aid in designing interventions in women to prevent HIV infection.

 

Awarded Project: "Defining Protective and Disease-Reducing Immunity to Borrelia Burgdorferi Infection"

September 30, 2018
Defining Protective and Disease-Reducing Immunity to Borrelia Burgdorferi Infection  

Dr. Nicole Baumgarth was awarded a three year project through the DoD Congressionally Directed Medical Research Program to work on a Lyme disease study.   Following infection with Borrelia burgdorferi, the causative agent of Lyme disease, antibodies are generated that can reduce the number of Borrelia in the infected host, but they cannot totally eliminate the infection.

Awarded Project: "Immune Mechanisms Underlying Age-Related Neurodegeneration in HIV Infection"

September 30, 2018
Immune Mechanisms Underlying Age-Related Neurodegeneration in HIV Infection

Dr. Smita Iyer received a fiver year grant from the National Institute on Aging, NIH to study age-related neurodegeneration related to HIV infection.  An estimated 50% of HIV-infected patients on antiretroviral therapy develop neurocognitive disorders. This proposal uses robust powerful and complementary approaches to understand the immune mechanisms underlying age- related neurodegeneration during HIV infection.

Awarded Project: "Bay Area CRISPR Reporters"

September 15, 2018
Bay Area CRISPR Reporters 

Dr. K.C. Kent Lloyd received a UC Multiple-Campus Award from the Office of the Director, NIH to participate with UCSF on Bay Area CRISPR Reporters.  A growing momentum and an ever-increasing body of evidence indicates that gene editing will become a standard treatment in therapeutic settings.  And although proof-of-principle and validation projects have demonstrated activity in cells and to some degree, in animal models, more work needs to be done in characterizing the activity of various gene  editing modalities.

Awarded Project: "Estrogen reverses progestin-mediated increases in susceptibility to genital virus pathogens"

September 01, 2018
Estrogen reverses progestin-mediated increases in susceptibility to genital virus pathogens 

Dr. Christopher J. Miller, in conjunction with Stanford University, received a five year grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development, NIH.  Prior work from our research group revealed that while depot-medroxyprogesterone acetate (DMPA) and other progestins used for contraception compromise genital mucosal barrier function, treatment of humanized mice with DMPA and estrogen (E) restores barrier integrity and blocks genital HIV transmission.

Article: "Prevention of HIV-1 transmission by CD4-mimetic small-molecule entry inhibitors"

July 01, 2018
Prevention of HIV-1 transmission by CD4-mimetic small-molecule entry inhibitors

Dr. Christopher J. Miller, in conjunction with the Dana-Farber Cancer Institute, Inc., received a four year grant from the National Institutes of Allergy and Infectious Diseases, NIH.  The global AIDS pandemic is sustained by continued sexual transmission of the etiologic agent, human immunodeficiency virus (HIV-1).

Awarded Project: "Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin Secretion"

May 31, 2018
Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin Secretion

Dr. Roger Sciammas recently received a two year grant from the National Institute of Allergy and Infectious Diseases (NIAID), NIH to study the “Role of the SET-like domain of Blimp-1 in plasma cell function and Immunoglobulin Secretion”.  Secreted antibodies are primary immunological proteins important for protection to microbial agents yet pathological if produced in excess. Because of this balance, the control of secretion is tightly regulated.