Teaching Program
CCM interdisciplinary research programs provide a rich academic environment for teaching at the professional, graduate and post-graduate levels within the School of Medicine and Veterinary Medicine. Opportunities are available for professional students from both schools to gain research experience in CCM faculty-sponsored research laboratories, Ph.D. training in graduate programs based in both schools, and postdoctoral training in CCM faculty-sponsored research laboratories. CCM faculty members are also involved in didactic teaching at the professional and graduate levels in their academic departments within both schools. This diverse teaching program, which interdigitates throughout both schools, is intended to attract and train high quality candidates to the disciplines of comparative medicine, infectious disease research, and laboratory animal sciences.
Training Program
Name of Resource: Comparative Medical Science Training Program
Address: Center for Comparative Medicine
Schools of Medicine and Veterinary Medicine
University of California, Davis
One Shields Avenue
Davis, CA 95616
URL: http://ccm.ucdavis.edu
Grant No.: T32 RR07038
Principal Investigator: Stephen W. Barthold, DVM, PhD
Professor and Director
Telephone: (530) 752-1245
Fax: (530) 752-7914
E-mail: swbarthold@ucdavis.edu
Additional Contact: Anita Moore
Assistant Director – Administration
Telephone: (530) 752-1245
Fax: (530) 752-7914
E-mail: afmoore@ucdavis.edu
Number of Trainees: Five trainees
Major Areas of Interest:
The UC Davis Comparative Medical Science Training Program provides graduate research training, leading to the PhD degree, for veterinarians who seek careers in biomedical research. The training program is based in the Center for Comparative Medicine, which is a research and graduate teaching center that is sponsored by the Schools of Medicine and Veterinary Medicine. The Center hosts faculty from both schools who are engaged in research utilizing animal models of human disease, with major areas of emphasis in infectious disease, cancer, and genomics. Mouse biology and pathology are also major areas of emphasis, as the Center oversees the UC Davis Mouse Biology Program, and an NCRR Mutant Mouse Regional Resource Center. The Center interfaces with the campus laboratory animal medicine program and the adjacent California National Primate Research Center, and residency programs in veterinary pathology and laboratory animal medicine. Students who matriculate into the program are placed with mentors within the Center, or with mentors in various programs in the School of Medicine or Veterinary Medicine, allowing customization of training emphasis to the interests of the student. The program fosters an appreciation for membership within the broad professional community of comparative medicine.
Index Terms: Comparative Medicine, comparative pathology, mouse biology, primate biology, infectious disease, cancer biology
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Name of Resource: Veterinary Student Research Training Program
Address: Center for Comparative Medicine
Schools of Medicine and Veterinary Medicine
University of California, Davis
One Shields Avenue
Davis, CA 95616
URL: http://ccm.ucdavis.edu
Grant No.: T35 RR07067
Principal Investigator: Stephen W. Barthold, DVM, PhD
Professor and Director
Telephone: (530) 752-1245
Fax: (530) 752-7914
E-mail: swbarthold@ucdavis.edu
Additional Contact: Anita Moore
Assistant Director – Administration
Telephone: (530) 752-1245
Fax: (530) 752-7914
E-mail: afmoore@ucdavis.edu
Number of Trainees: Nine trainees
Major Areas of Interest:
The UC Davis Veterinary Student Research Training Program provides summer research training to veterinary students. The overall objective of the program is to place interested students with mentors in active laboratories that are engaged in biomedical research. Students are fully immersed in NIH-funded laboratories in order to not only achieve experience in research, but an appreciation for the importance of research to the veterinary profession. The training program is based in the Center for Comparative Medicine, which is a research and graduate teaching center that is sponsored by the Schools of Medicine and Veterinary Medicine. The Center hosts faculty from both schools who are engaged in research utilizing animal models of human disease, with major areas of emphasis in infectious disease, cancer, and genomics. Mouse biology and pathology are also major areas of emphasis, as the Center oversees the UC Davis Mouse Biology Program, and an NCRR Mutant Mouse Regional Resource Center. The Center interfaces with the campus laboratory animal medicine program and the adjacent California National Primate Research Center, and residency programs in veterinary pathology and laboratory animal medicine. Students are placed with mentors within the Center, or with mentors in various programs in the School of Medicine or Veterinary Medicine, allowing customization of training emphasis to the interests of the student. In addition to research exposure, students engage in seminars on ethics of animal-related research, safety, animal models of human disease, and symposia in which they present their research progress.
Index Terms: Comparative Medicine, comparative pathology, mouse biology, primate biology, infectious disease, cancer biology
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Name of Resource: UC Davis Mutant Mouse Regional Resource Center
Address: Center for Comparative Medicine
Schools of Medicine and Veterinary Medicine
University of California, Davis
One Shields Avenue
Davis, CA 95616
URL: http://ccm.ucdavis.edu
Grant No.: U42 RR14905
Principal Investigator: Stephen W. Barthold, DVM, PhD
Professor and Director
Telephone: (530) 752-1245
Fax: (530) 752-7914
E-mail: swbarthold@ucdavis.edu
Additional Contact: K.C. Kent Lloyd, DVM, PhD
Telephone: (530) 754-4322
Fax: (530) 752-7914
E-mail: kclloyd@ucdavis.edu
Research Emphasis/Objectives:
The overall objective of the UC Davis Mutant Mouse Regional Resource Center is to serve as a component of the MMRRC National Program, to accept, maintain, and distribute mutant mice for use in biomedical research. The MMRRC Program accepts transgenics, knockouts, and all other kinds of mutant mouse lines at no cost to the donor, and after re-derivation and cryopreservation, distributes breeding stock or germplasm of genetically-defined and pathogen-free mice at a small fee to requesting investigators. The UC Davis MMRRC currently has a census of over 10,000 mutant strains that are maintained as live breeding colonies, frozen embryos or germplasm, and embryonic stem cell clones. Furthermore, the MMRRC serves as a center of excellence in mouse biology, mouse genomic manipulation, genetic and genotyping services, strain rescue, pathology and clinical pathology phenotyping, behavioral phenotyping, non-invasive imaging, and infectious disease diagnostics. These services are available to the biomedical research community on a collaborative or fee-for-service basis. The MMRRC provides support for applied research that is aimed at enhancing the resource, and serves as a teaching environment that is linked to residency and graduate training programs in the Center for Comparative Medicine.
Current Research:
Areas of applied research that are supported by the MMRRC include evaporative drying of mouse sperm, oocyte and blastocyst cryopreservation, accelerated speed congenics, development of optimized SNPs, multiplex detection of antibody to infectious agents, and vertical transmission of infectious agents through germplasm.
Services Provided:
Cryopreservation, rederivation, strain rescue, construct design, random and targeted mutations, speed congenics, genotyping, in vitro fertilization, intracytoplasmic sperm injection, pathology and behavioral phenotyping, diagnostics, experimental pathology, non-invasive imaging, data and image analysis, colony management, and teaching resources.
Index Terms:
Mutant mouse, mouse biology, mouse diagnostics, mouse pathology, germplasm, cryopreservation, non-invasive imaging, behavior
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Name of Resource: Animal Models of Infectious Diseases Training Program
Address: Center for Comparative Medicine
Schools of Medicine and Veterinary Medicine
University of California, Davis
One Shields Avenue
Davis, CA 95616
URL: http://ccm.ucdavis.edu
Grant No.: 5T32AI060555-03
Principal Investigator: Jay V. Solnick, MD, PhD
Professor
Departments of Medicine and Medical Microbiology
Telephone: (530) 752-1333
Fax: (530) 752-7914
E-mail: jvsolnick@ucdavis.edu
Additional Contact: Anita Moore
Assistant Director – Administration
Telephone: (530) 752-1245
Fax: (530) 752-7914
E-mail: afmoore@ucdavis.ed
Number of Trainees: Seven trainees
Major Areas of Interest:
The UC Davis Animal Models of Infectious Diseases Training Program provides support for predoctoral and postdoctoral (DVM or MD) students who seek research training leading to the PhD degree. The program seeks to train talented students to conduct studies of human infectious diseases by exploiting animal models and novel biological methods that are evolving from the revolutions in genomics and bioinformatics. The co-localization of the Graduate School , the Schools of Medicine and Veterinary Medicine, and the California National Primate Research Center combine to make UC Davis a unique environment in which to conduct this training. The environment is further enhanced by the Center for Camparative Medicine and by a major genomics initiative at UC Davis, which is housed in the Genome and Biomedical Sciences Building that opened in 2004. The mentors for the training program are established investigators at UC Davis, whose work uses animal primarily mouse and primate models to better understand viral and bacterial human pathogens. Training emphasizes rigorous scientific research, oral and written scientific communication, and interaction with a broad range of scientists interested in animal models of human infectious diseases.
