In recent years a remarkable evolutionary conservation of innate immune mechanisms has become apparent between flies, plants, mice and humans. Each of these species uses similar receptors to detect microbes. Therapeutic targeting of toll-like receptors for infectious and inflammatory disease and cancer and crop engineering of these receptors for resistance to infection is now a reality.

Speakers of this symposium will include talks by Nobel Laureates and pioneer investigators who discovered these receptors: in plants, Dr. Pamela Ronald, UC Davis; in Drosophila, Dr. Jules Hoffmann, University of Strasbourg; and in mice, Dr. Bruce Beutler, University of Texas Southwestern Medical Center. The role of these receptors in driving inflammatory diseases of humans will be summarized by Dr. Luke O'Neill, Trinity College of Dublin.

 

Audio/Video PowerPoint Presentations:

"The Drosophila Host Defense: A Model for the Study of Innate Immunity"  by Jules Hoffmann, PhD, 2011 Nobel Laureate in Physiology or Medicine University of Strasbourg, Strasbourg

“Creating Immune Deficiencies by Random Mutagenesis in Mammals” by Bruce Beutler, MD, 2011 Nobel Laureate in Physiology or Medicine UT Southwestern Medical Center, Dallas

“The Rice XA21 Receptor Recognizes a Conserved Bacterial Signaling Molecule” by Pamela Ronald, PhD, Professor Department of Plant Pathology, UC Davis Genome Center, University of California, Davis

“Toll-like Receptors and Inflammasomes:  Key Drivers of Inflammatory Diseases” by Luke O'Neill, PhD, Professor School of Biochemistry and Immunology, Trinity College, Dublin

From left to right Drs. Bruce Beutler, Jules Hoffmann, Luke O'Neill, Pamela Ronald, and Murray Gardner

If you would like more information,
Please contact:
Anita Moore (530) 752-1245
afmoore@ucdavis.edu