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Examples illustrating the various descriptors and modiŽers used in Tables 2 and 3 to characterize the patterns observed in GEM.
(a) is glandular with glands dilated by secretions. This image is from a WAP/TGF a tumor;
(b) is acinar with small glandular structure with small lumens and minimal secretions. The image is from a MMTV-Wnt10b tumor;
(c) is cribriform with back-to- back glands. The image is from a MMTV/myc tumor;
(d) is papillary well differentiated with finger-like projects of fibrovascular stroma covered with neoplastic epithelium. This image is from a MTV/TGF a mouse;
(e) is solid with sheets of tumor cells with little or no intervening stroma. This image is from a MMTV/DNIIR tumor;
(f) is sclerotic with a dense connective tissue stroma separating strands of invasive tumor cells. This image is from a MMTV/int-3 tumor;
(g) shows invasion between muscle fibers in a bigenic WAP/TGF a6WAP/myc tumor;
(h) shows an expansile non-invasive pattern at the edge of an adenoma and lactating mammary gland in a bigenic WAP/p53 ą 1726WAP/TGF a mouse;
(i) has necrosis at the center of a dilated glandular structure. This image is from a BLG/igf-2 tumor;
(j) is a carcinosarcoma tumor with sarcomatous and carcinomatous components from a WAP/stromelysin-1 mouse;
(k) is a mammary tumor with cartilaginous and osseous metaplasia from a WAP/stromelysin-1 mouse;
(l) is an adenocarcinoma from a MMTV/heregulin mouse. The scale bar indicates 100 microns
Use of figure and legend is courtesy of Oncogene (nature publishing group)
Cardiff et al, Oncogene (2000) 19, 968-988