|
|
|
| |
|
|
MODIFIERS |
|
|
|
|
Carcinoma |
Neoplasm originating from epithelium with proven malignant biological behavior. |
|
|
|
Adenocarcinoma |
Neoplasm originating from glandular epithelium with proven malignant biological behavior. |
|
|
|
Adenoma |
Neoplasm originating from glandular epithelium Without proven malignant biological behavior. |
|
|
|
Mammary Intraepithelial Neoplasia (MIN) |
An intraluminal epithelial mass with cytologic atypia. |
|
|
|
Hyperplasia |
Any increase in cell number without cytologic atypia. | ||
|
Tumor |
Any space occupying mass with unknown biological potential. | ||
| Property: | |||
|
Atypia |
Cells with abnormal nuclear morphology. | ||
|
Necrosis |
Cell death generally not applied to programmed Cell death (apoptosis). |
|
|
|
Fibrosis |
Increased or abnormal deposition of connective Tissue. |
|
|
|
Secretory |
Tissues or glands producing and exporting lipid or protein |
|
|
|
Metaplasia |
A change from one adult cell type to another adult Cell type. |
|
|
| Topographic: | |||
|
Diffuse |
All of the mammary gland is involved in the process. | ||
|
Focal |
One area of the mammary gland is involved in the process. |
||
|
Multifocal |
Multiple foci are of the mammary gland have The lesion. |
||
| Inducer (Etiology): | |||
|
Gene-induced |
Tumors that have morphological or cytological Patterns characteristic of specific transgenes or Specific mutations. (myc-type, ras-type, erbB2-type) |
|
|
|
MMTV-induced |
Tumors known to be induced by the Mouse Mammary Tumor Virus (MMTV). |
|
|
|
Chemically -induced |
Tumors known to be induced by a chemical carcinogen. |
|
|
|
Hormone-induced |
Tumors known to be induced by exogenous hormones | ||
|
Biological |
Parity, Pregnancy, Lactation, Involution, Hormones | ||
|
Experimental |
promotor, exogenous hormones or chemicals | ||
Use of table and images is courtesy of Oncogene (nature publishing group)
Cardiff et al, Oncogene (2000) 19, 968-988
