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| Molecular lesions causing breast cancer in human have proven to cause breast cancer in Genetically Engineered Mice. | Some molecular lesions causing breast cancer in mice have not been found in human breast cancer. | Discussion |
| Similar morphological patterns of lesions appear in both species | The morphology of most mouse tumors does not resemble the common human breast cancers. | Discussion |
| Development of cancer consistent with multi-hit kinetics. | Some transgenes appear to be associated with one-hit kinetics. | Discussion |
| Breast cancers in both species are metastatic. | Most tumors mouse metastasize to the lung. Most human metastasize to the regional lymph nodes. | Discussion |
| Both species have distinctive host responses to the cancers. | The mouse generally does not respond to its tumor with as much fibrosis and inflammation. | Discussion |
| Breast cancer is frequently hormone independent. | Half of human breast cancers are hormone independent. Most mouse tumors are hormone independent. | Discussion |