As the woman ages, the lobule also undergoes
characteristic atrophy. This set of images show the typical changes.
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This "Normal" lobule is from a non-pregnant 49 year old female with breast cancer. It has the appearance of a younger female. However, women with breast cancer retain a youthful breast parenchyma.
This normal lobule is from a 43 year old female with no breast cancer. Note the thickened basement membranes around the ductules. The lobule is starting to become sclerotic.
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This normal lobule displays fewer ductules and denser intralobular stroma. Non-cancerous breast from an 83 year old female.
In this breast slice the lobules show moderate atrophy. Note the distended duct tree. From a 59 year old female with no breast cancer.